Each year, fishermen from all over the country come to Mobile to try to catch the largest fish in almost 40 categories, including “most unusual.” Unlike other tournaments in the area where anglers only have one day to catch, in the Alabama Deep Sea Fishing Rodeo, fisherman can stay out for three days and two nights straight.

The Azalea Trail Run is an annual spring race held in Mobile, Alabama and is considered one of the United States' premier road races. Runners, walkers, and wheelchair athletes from around the world and at all levels turn out for the event. The 10 kilometer race is known for its fast, flat course along Mobile’s oak shaded streets and has seen blistering records set by runners since its inception.  The two-day family, friendly event was founded in 1978 and includes a world class 10K race, a fun run, and a Health and Fitness Expo. The Azalea Trail Run is produced by the Port City Pacers, a local nonprofit organization with the mission of promoting health and fitness through running and walking.

The Senior Bowl is a post-season college football exhibition game played in Mobile, Alabama which showcases the best NFL draft prospects of those collegiate players who have completed their eligibility. First played in 1950 in Jacksonville, Florida, the game moved to Mobile's Ladd Peebles Stadium the next year. Produced by the non-profit Mobile Arts & Sports Association, the game is also a charitable fund-raiser benefiting various local and regional organizations with over US$5.9 million in donations over its history.  The telecast moved to the NFL Network from ESPN beginning in 2007.

The GMAC Bowl is a post-season NCAA-sanctioned Division I Football Bowl Subdivision college football bowl game that has been played annually at Ladd Peebles Stadium since 1999. It pits a Conference USA team (home team) against a team from either the Mid-American Conference or the Western Athletic Conference. The game was previously known as the Mobile Alabama Bowl from 1999 to 2000 until it received corporate sponsorship from GMAC Financial Services, formerly a unit of General Motors.